GluR-δ2 Polyclonal Antibody
- 货号：YT1927
- 应用：WB;IF;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>Neuroactive ligand-receptor interaction;>>Long-term depression
- 蛋白名称：
- Glutamate receptor delta-2 subunit
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880
- 特异性：
- GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- GRID2;GLURD2;Glutamate receptor delta-2 subunit;GluR delta-2 subunit
- 背景：
- The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this
- 功能：
- domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2.,
- 细胞定位：
- Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein .
- 组织表达：
- Brain,Cerebellum,PCR rescued clones,
- Western Blot analysis of 3T3 cells using GluR-δ2 Polyclonal Antibody
- Immunofluorescence analysis of HUVEC cells, using GRID2 Antibody. The picture on the right is blocked with the synthesized peptide.
- Western blot analysis of lysates from mouse brain, using GRID2 Antibody. The lane on the right is blocked with the synthesized peptide.
