• 靶点：
• GluR-5

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Glutamatergic synapse

• 基因名称：
• GRIK1

• 蛋白名称：
• Glutamate receptor ionotropic kainate 1

• Human Gene Id：
• 2897

• Human Swiss Prot No：
• P39086

• Mouse Swiss Prot No：
• Q60934

• Rat Gene Id：
• 29559

• Rat Swiss Prot No：
• P22756

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GluR5. AA range:10-59

• 特异性：
• GluR-5 Polyclonal Antibody detects endogenous levels of GluR-5 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GRIK1;GLUR5;Glutamate receptor; ionotropic kainate 1;Excitatory amino acid receptor 3;EAA3;Glutamate receptor 5;GluR-5;GluR5

• 实测条带：
• 100kD

• 背景：
• Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• alternative products:Additional isoforms seem to exist,function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA.,RNA editing:Partially edited.,simila

• 细胞定位：
• Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

• 组织表达：
• Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.

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