• 靶点：
• GluR4

• 简介：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Circadian entrainment;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Dopaminergic synapse;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases;>>Amphetamine addiction;>>Nicotine addiction

• 基因名称：
• GRIA4

• 蛋白名称：
• Glutamate receptor 4

• Human Gene Id：
• 2893

• Human Swiss Prot No：
• P48058

• Mouse Gene Id：
• 14802

• Mouse Swiss Prot No：
• Q9Z2W8

• Rat Gene Id：
• 29629

• Rat Swiss Prot No：
• P19493

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GluR4. AA range:828-877

• 特异性：
• GluR4 Polyclonal Antibody detects endogenous levels of GluR4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GRIA4;GLUR4;Glutamate receptor 4;GluR-4;GluR4;AMPA-selective glutamate receptor 4;GluR-D;Glutamate receptor ionotropic; AMPA 4;GluA4

• 实测条带：
• 100kD

• 背景：
• Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008],

• 功能：
• function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regul

• 细胞定位：
• Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. .

• 组织表达：
• Brain,Donated clones,PCR rescued clones,

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