• 靶点：
• GHRH-R

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Growth hormone synthesis, secretion and action

• 基因名称：
• GHRHR

• 蛋白名称：
• Growth hormone-releasing hormone receptor

• Human Gene Id：
• 2692

• Human Swiss Prot No：
• Q02643

• Mouse Gene Id：
• 14602

• Mouse Swiss Prot No：
• P32082

• Rat Gene Id：
• 25321

• Rat Swiss Prot No：
• Q02644

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GHRHR. AA range:351-400

• 特异性：
• GHRH-R Polyclonal Antibody detects endogenous levels of GHRH-R protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GHRHR;Growth hormone-releasing hormone receptor;GHRH receptor;Growth hormone-releasing factor receptor;GRF receptor;GRFR

• 实测条带：
• 47kD

• 背景：
• This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010],

• 功能：
• disease:Defects in GHRHR are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which cause short stature.,function:Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Pituitary gland.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Pituitary gland.

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