• 靶点：
• Gastrin

• 简介：
• >>Gastric acid secretion

• 基因名称：
• GAST

• 蛋白名称：
• Gastrin

• Human Gene Id：
• 2520

• Human Swiss Prot No：
• P01350

• Mouse Gene Id：
• 14459

• Mouse Swiss Prot No：
• P48757

• Rat Gene Id：
• 25320

• Rat Swiss Prot No：
• P04563

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Gastrin. AA range:52-101

• 特异性：
• Gastrin Polyclonal Antibody detects endogenous levels of Gastrin protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GAST;GAS;Gastrin

• 实测条带：
• 12kD

• 背景：
• Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008],

• 功能：
• function:Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.,online information:Gastrin entry,PTM:Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.,PTM:Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resul

• 细胞定位：
• Secreted.

• 组织表达：
• Gastric mucosa,

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