GASP-1 Polyclonal Antibody
- 货号：YT1856
- 应用：IHC;IF;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- G-protein coupled receptor-associated sorting protein 1
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human GASP1. AA range:741-790
- 特异性：
- GASP-1 Polyclonal Antibody detects endogenous levels of GASP-1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- GPRASP1;GASP;KIAA0443;G-protein coupled receptor-associated sorting protein 1;GASP-1
- 背景：
- This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010],
- 功能：
- function:May modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes.,similarity:Belongs to the GPRASP family.,subunit:Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1.,tissue specificity:Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.,
- 组织表达：
- Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.
- Immunofluorescence analysis of A549 cells, using GASP1 Antibody. The picture on the right is blocked with the synthesized peptide.
- Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GASP1 Antibody. The picture on the right is blocked with the synthesized peptide.
