GABAA Rα4 Polyclonal Antibody
- 货号：YT1822
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Taste transduction;>>Morphine addiction;>>Nicotine addiction
- 蛋白名称：
- Gamma-aminobutyric acid receptor subunit alpha-4
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human GABRA4. AA range:81-130
- 特异性：
- GABAA Rα4 Polyclonal Antibody detects endogenous levels of GABAA Rα4 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- GABRA4;Gamma-aminobutyric acid receptor subunit alpha-4;GABA(A) receptor subunit alpha-4
- 背景：
- Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],
- 功能：
- function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
- 细胞定位：
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
- 组织表达：
- Brain,Brain cortex,
- Western Blot analysis of various cells using GABAA Rα4 Polyclonal Antibody diluted at 1:1000
- Western blot analysis of GABRA4 Antibody. The lane on the right is blocked with the GABRA4 peptide.
- Western blot analysis of the lysates from COLO205 cells using GABRA4 antibody.
