FRP-2 Polyclonal Antibody
- 货号:YT1790
- 应用:WB;ELISA
- 种属:Human;Mouse;Rat
- 简介:
- >>Wnt signaling pathway
- 蛋白名称:
- Secreted frizzled-related protein 2
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human SFRP2. AA range:119-168
- 特异性:
- FRP-2 Polyclonal Antibody detects endogenous levels of FRP-2 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- SFRP2;FRP2;SARP1;FKSG12;Secreted frizzled-related protein 2;FRP-2;sFRP-2;Secreted apoptosis-related protein 1;SARP-1
- 背景:
- This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008],
- 功能:
- domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.,tissue specificity:Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.,
- 组织表达:
- Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.
![](/uploadfiles/PIC/yt1790-wb.jpg)
- Western Blot analysis of various cells using FRP-2 Polyclonal Antibody diluted at 1:500
![](/uploadfiles/PIC/yt1790-wb(2).jpg)
- Western Blot analysis of HuvEc cells using FRP-2 Polyclonal Antibody diluted at 1:500
![](/uploadfiles/PIC/yt1790_pic751218522.jpg)
- Western blot analysis of lysates from HeLa, COLO, and HUVEC cells, using SFRP2 Antibody. The lane on the right is blocked with the synthesized peptide.