• 靶点：
• FPR1

• 简介：
• >>Rap1 signaling pathway;>>Neuroactive ligand-receptor interaction;>>Neutrophil extracellular trap formation;>>Staphylococcus aureus infection

• 基因名称：
• FPR1

• 蛋白名称：
• fMet-Leu-Phe receptor

• Human Gene Id：
• 2357

• Human Swiss Prot No：
• P21462

• Mouse Swiss Prot No：
• P33766

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human FPR1. AA range:155-204

• 特异性：
• FPR1 Polyclonal Antibody detects endogenous levels of FPR1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FPR1;fMet-Leu-Phe receptor;fMLP receptor;N-formyl peptide receptor;FPR;N-formylpeptide chemoattractant receptor

• 实测条带：
• 40kD

• 背景：
• formyl peptide receptor 1(FPR1) Homo sapiens This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010],

• 功能：
• function:High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.,PTM:Phosphorylated; which is necessary for desensitization.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Neutrophils.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Internalizes in presence of its ligands, fMLP, TAFA4 and CTSG. .

• 组织表达：
• Neutrophils.

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