• 靶点：
• Follistatin

• 简介：
• >>TGF-beta signaling pathway

• 基因名称：
• FST

• 蛋白名称：
• Follistatin

• Human Gene Id：
• 10468

• Human Swiss Prot No：
• P19883

• Mouse Gene Id：
• 14313

• Mouse Swiss Prot No：
• P47931

• Rat Gene Id：
• 24373

• Rat Swiss Prot No：
• P21674

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human FST. AA range:121-170

• 特异性：
• Follistatin Polyclonal Antibody detects endogenous levels of Follistatin protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FST;Follistatin;FS;Activin-binding protein

• 实测条带：
• 65kD

• 背景：
• Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008],

• 功能：
• function:Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).,similarity:Contains 1 TB (TGF-beta binding) domain.,similarity:Contains 3 follistatin-like domains.,similarity:Contains 3 Kazal-like domains.,subunit:Monomer .,tissue specificity:Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.,

• 细胞定位：
• Secreted.

• 组织表达：
• Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115).

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