• 靶点：
• EP4

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Inflammatory mediator regulation of TRP channels;>>Renin secretion;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Pathways in cancer

• 基因名称：
• PTGER4

• 蛋白名称：
• Prostaglandin E2 receptor EP4 subtype

• Human Gene Id：
• 5734

• Human Swiss Prot No：
• P35408

• Mouse Swiss Prot No：
• P32240

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PE2R4. AA range:321-370

• 特异性：
• EP4 Polyclonal Antibody detects endogenous levels of EP4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PTGER4;PTGER2;Prostaglandin E2 receptor EP4 subtype;PGE receptor EP4 subtype;PGE2 receptor EP4 subtype;Prostanoid EP4 receptor

• 实测条带：
• 55kD

• 背景：
• The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008],

• 功能：
• caution:Was originally designated as the EP2 subtype.,function:Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FEM1A.,tissue specificity:High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.

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