• 靶点：
• EMR3

• 基因名称：
• EMR3

• 蛋白名称：
• EGF-like module-containing mucin-like hormone receptor-like 3

• Human Gene Id：
• 84658

• Human Swiss Prot No：
• Q9BY15

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human EMR3. AA range:603-652

• 特异性：
• EMR3 Polyclonal Antibody detects endogenous levels of EMR3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• EMR3;EGF-like module-containing mucin-like hormone receptor-like 3;EGF-like module receptor 3

• 实测条带：
• 70kD

• 背景：
• This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014],

• 功能：
• function:Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils.,PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 2 EGF-like domains.,subcellular location:A soluble form is also detected (alpha subunit).,subunit:Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit).,tissue specificity:Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein .; [Isoform 3]: Secreted.

• 组织表达：
• Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages.

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