Elongin A2/3 Polyclonal Antibody
- 货号：YT1533
- 应用：IF;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- RNA polymerase II transcription factor SIII subunit A2/3
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human ELOA2. AA range:101-150
- 特异性：
- Elongin A2/3 Polyclonal Antibody detects endogenous levels of Elongin A2/3 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TCEB3B;TCEB3L;RNA polymerase II transcription factor SIII subunit A2;Elongin-A2;EloA2;Transcription elongation factor B polypeptide 3B;TCEB3C;TCEB3L2;RNA polymerase II transcription factor SIII subunit A3;Elongin-A3;EloA3;Transcr
- 背景：
- This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008],
- 功能：
- domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,function:SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).,similarity:Contains 1 TFIIS N-terminal domain.,subunit:Heterotrimer of an A (A1, A2 or A3), B and C subunit.,tissue specificity:Specifically expressed in testis.,
- 组织表达：
- Specifically expressed in testis.
- Immunofluorescence analysis of A549 cells, using ELOA2 Antibody. The picture on the right is blocked with the synthesized peptide.
