EAT-2 Polyclonal Antibody
- 货号：YT1451
- 应用：IHC;IF;ELISA
- 种属：Human;Mouse
- 简介：
- >>Natural killer cell mediated cytotoxicity
- 蛋白名称：
- SH2 domain-containing protein 1B
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human SH2D1B. AA range:71-120
- 特异性：
- EAT-2 Polyclonal Antibody detects endogenous levels of EAT-2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- SH2D1B;EAT2;SH2 domain-containing protein 1B;EWS/FLI1-activated transcript 2;EAT-2
- 背景：
- By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008],
- 功能：
- function:Plays a role in controlling signal transduction through at least four receptors, CD84, CD150, CD229 and CD244, expressed on the surface of professional antigen-presenting cells.,similarity:Contains 1 SH2 domain.,subunit:Binds to the phosphorylated receptors CD84, CD150, CD229 and CD244. Does not bind to non-phosphorylated CD150.,
- 细胞定位：
- intracellular,cytosol,
- 组织表达：
- Leukocyte,Lung,Spleen,
- Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using SH2D1B Antibody. The picture on the right is blocked with the synthesized peptide.
