• 靶点：
• DSCR 1

• 简介：
• >>Thyroid hormone signaling pathway;>>Oxytocin signaling pathway;>>Kaposi sarcoma-associated herpesvirus infection

• 基因名称：
• RCAN1

• 蛋白名称：
• Calcipressin-1

• Human Gene Id：
• 1827

• Human Swiss Prot No：
• P53805

• Mouse Gene Id：
• 54720

• Mouse Swiss Prot No：
• Q9JHG6

• Rat Gene Id：
• 266766

• Rat Swiss Prot No：
• Q6IN33

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human RCAN1. AA range:201-250

• 特异性：
• DSCR 1 Polyclonal Antibody detects endogenous levels of DSCR 1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RCAN1;ADAPT78;CSP1;DSC1;DSCR1;Calcipressin-1;Adapt78;Down syndrome critical region protein 1;Myocyte-enriched calcineurin-interacting protein 1;MCIP1;Regulator of calcineurin 1

• 实测条带：
• 22kD

• 背景：
• The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],

• 功能：
• function:Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.,induction:By calcium.,similarity:Belongs to the RCAN family.,tissue specificity:Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.,

• 细胞定位：
• intracellular,nucleus,cytoplasm,

• 组织表达：
• Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

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