DCAMKL2 Polyclonal Antibody
- 货号：YT1298
- 应用：WB;IF;ELISA
- 种属：Human;Mouse
- 蛋白名称：
- Serine/threonine-protein kinase DCLK2
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human DCLK2. AA range:1-50
- 特异性：
- DCAMKL2 Polyclonal Antibody detects endogenous levels of DCAMKL2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- DCLK2;DCAMKL2;DCDC3B;DCK2;Serine/threonine-protein kinase DCLK2;CaMK-like CREB regulatory kinase 2;CL2;CLICK-II;CLICK2;Doublecortin domain-containing protein 3B;Doublecortin-like and CAM kinase-like 2;Doublecortin-like kinase 2
- 背景：
- This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alterna
- 功能：
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 doublecortin domains.,
- 细胞定位：
- Cytoplasm, cytoskeleton. Colocalizes with microtubules. .
- 组织表达：
- Expressed in the brain, heart and eyes.
- Western Blot analysis of various cells using DCAMKL2 Polyclonal Antibody
- Western blot analysis of lysates from HepG2 cells, using DCLK2 Antibody. The lane on the right is blocked with the synthesized peptide.
