• 靶点：
• CYP2S1

• 简介：
• >>Retinol metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Metabolic pathways

• 基因名称：
• CYP2S1

• 蛋白名称：
• Cytochrome P450 2S1

• Human Gene Id：
• 29785

• Human Swiss Prot No：
• Q96SQ9

• Mouse Gene Id：
• 74134

• Mouse Swiss Prot No：
• Q9DBX6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2S1. AA range:181-230

• 特异性：
• CYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CYP2S1;Cytochrome P450 2S1;CYPIIS1

• 实测条带：
• 56kD

• 背景：
• This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Has a potential importance for extrahepatic xenobiotic metabolism.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:High level of expression in trachea, lung, stomach, small intestine, and spleen.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .

• 组织表达：
• Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469).

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