• 靶点：
• CYP1A1/2

• 简介：
• >>Steroid hormone biosynthesis;>>Tryptophan metabolism;>>Retinol metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Metabolic pathways;>>Ovarian steroidogenesis;>>Chemical carcinogenesis - DNA adducts;>>Chemical carcinogenesis - receptor activation;>>Chemical carcinogenesis - reactive oxygen species;>>Lipid and atherosclerosis

• 基因名称：
• CYP1A1/CYP1A2

• 蛋白名称：
• Cytochrome P450 1A1/2

• Human Gene Id：
• 1543/1544

• Human Swiss Prot No：
• P04798/P05177

• Mouse Gene Id：
• 13076/13077

• Rat Gene Id：
• 24296/24297

• Rat Swiss Prot No：
• P00185/P04799

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Cytochrome P450 1A1/2. AA range:71-120

• 特异性：
• CYP1A1/2 Polyclonal Antibody detects endogenous levels of CYP1A1/2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CYP1A1;Cytochrome P450 1A1;CYPIA1;Cytochrome P450 form 6;Cytochrome P450-C;Cytochrome P450-P1;CYP1A2;Cytochrome P450 1A2;CYPIA2;Cytochrome P(3)450;Cytochrome P450 4;Cytochrome P450-P3

• 实测条带：
• 58kD

• 背景：
• This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016],

• 功能：
• catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.,induction:By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).,online information:CYP1A1 alleles,online information:CYP1A1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Lung, lymphocytes and placenta.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion inner membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein . Cytoplasm .

• 组织表达：
• Lung, lymphocytes and placenta.

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