• 靶点：
• CYP19A1

• 简介：
• >>Steroid hormone biosynthesis;>>Metabolic pathways;>>Ovarian steroidogenesis

• 基因名称：
• CYP19A1

• 蛋白名称：
• Cytochrome P450 19A1

• Human Gene Id：
• 1588

• Human Swiss Prot No：
• P11511

• Mouse Gene Id：
• 13075

• Mouse Swiss Prot No：
• P28649

• Rat Swiss Prot No：
• P22443

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Cytochrome P450 19A1. AA range:221-270

• 特异性：
• CYP19A1 Polyclonal Antibody detects endogenous levels of CYP19A1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CYP19A1;ARO1;CYAR;CYP19;Cytochrome P450 19A1;Aromatase;CYPXIX;Cytochrome P-450AROM;Estrogen synthase

• 实测条带：
• 53kD

• 背景：
• cytochrome P450 family 19 subfamily A member 1(CYP19A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

• 功能：
• catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,disease:Defects in CYP19A1 are a cause of familial gynecomastia [MIM:139300]. This is characterized by an estrogen excess due to an increased aromatase activity.,disease:Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.,function:Catalyzes the formation of aromatic C18 estrogens from C19 androgens.,online information:

• 细胞定位：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .

• 组织表达：
• Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.

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