• 靶点：
• Cyclophilin F

• 简介：
• >>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Neutrophil extracellular trap formation;>>Alzheimer disease;>>Parkinson disease;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Toxoplasmosis;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy

• 基因名称：
• PPIF

• 蛋白名称：
• Peptidyl-prolyl cis-trans isomerase F mitochondrial

• Human Gene Id：
• 10105

• Human Swiss Prot No：
• P30405

• Mouse Gene Id：
• 105675

• Mouse Swiss Prot No：
• Q99KR7

• Rat Gene Id：
• 282819

• Rat Swiss Prot No：
• P29117

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PPIF. AA range:86-135

• 特异性：
• Cyclophilin F Polyclonal Antibody detects endogenous levels of Cyclophilin F protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PPIF;CYP3;Peptidyl-prolyl cis-trans isomerase F; mitochondrial;PPIase F;Cyclophilin F;Rotamase F

• 实测条带：
• 22kD

• 背景：
• The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Contains 1 PPIase cyclophilin-type domain.,

• 细胞定位：
• Mitochondrion matrix .

• 组织表达：
• Blood,Cord blood,Ovary,

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