• 靶点：
• CTPS

• 简介：
• >>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors

• 基因名称：
• CTPS1

• 蛋白名称：
• CTP synthase 1

• Human Gene Id：
• 1503

• Human Swiss Prot No：
• P17812

• Mouse Gene Id：
• 51797

• Mouse Swiss Prot No：
• P70698

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CTPS. AA range:60-109

• 特异性：
• CTPS Polyclonal Antibody detects endogenous levels of CTPS protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CTPS1;CTPS;CTP synthase 1;CTP synthetase 1;UTP--ammonia ligase 1

• 实测条带：
• 67kD

• 背景：
• This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

• 功能：
• catalytic activity:ATP + UTP + NH(3) = ADP + phosphate + CTP.,enzyme regulation:Activated by GTP and inhibited by CTP.,function:Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.,pathway:Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.,similarity:Belongs to the CTP synthase family.,similarity:Contains 1 glutamine amidotransferase type-1 domain.,

• 细胞定位：
• Cytoplasm, cytosol . Mainly cytosolic but when active detected in long filamentous structures (PubMed:25223282). Co-localizes with TNK2 in the cytosolic filaments (By similarity). .

• 组织表达：
• Widely expressed.

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