• 靶点：
• CRF-RII

• 简介：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Cushing syndrome

• 基因名称：
• CRHR2

• 蛋白名称：
• Corticotropin-releasing factor receptor 2

• Human Gene Id：
• 1395

• Human Swiss Prot No：
• Q13324

• Mouse Swiss Prot No：
• Q60748

• Rat Gene Id：
• 64680

• Rat Swiss Prot No：
• P47866

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CRHR2. AA range:71-120

• 特异性：
• CRF-RII Polyclonal Antibody detects endogenous levels of CRF-RII protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CRHR2;CRF2R;CRH2R;Corticotropin-releasing factor receptor 2;CRF-R-2;CRF-R2;CRFR-2;Corticotropin-releasing hormone receptor 2;CRH-R-2;CRH-R2

• 实测条带：
• 48kD

• 背景：
• The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],

• 功能：
• function:This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Amygdala,Brain,Skeletal muscle,

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