• 靶点：
• CPI-17

• 简介：
• >>Vascular smooth muscle contraction

• 基因名称：
• PPP1R14A

• 蛋白名称：
• Protein phosphatase 1 regulatory subunit 14A

• Human Gene Id：
• 94274

• Human Swiss Prot No：
• Q96A00

• Mouse Gene Id：
• 68458

• Mouse Swiss Prot No：
• Q91VC7

• Rat Gene Id：
• 114004

• Rat Swiss Prot No：
• Q99MC0

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CPI17 alpha. AA range:5-54

• 特异性：
• CPI-17 Polyclonal Antibody detects endogenous levels of CPI-17 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PPP1R14A;CPI17;PPP1INL;Protein phosphatase 1 regulatory subunit 14A;17 kDa PKC-potentiated inhibitory protein of PP1;Protein kinase C-potentiated inhibitor protein of 17 kDa;CPI-17

• 实测条带：
• 22kD

• 背景：
• The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011],

• 功能：
• function:Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.

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