• 靶点：
• COL19A1

• 简介：
• >>Protein digestion and absorption

• 基因名称：
• COL19A1

• 蛋白名称：
• Collagen alpha-1(XIX) chain

• Human Gene Id：
• 1310

• Human Swiss Prot No：
• Q14993

• Mouse Swiss Prot No：
• Q0VF58

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Collagen XIX alpha1. AA range:421-470

• 特异性：
• COL19A1 Polyclonal Antibody detects endogenous levels of COL19A1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• COL19A1;Collagen alpha-1(XIX) chain;Collagen alpha-1(Y) chain

• 实测条带：
• 120kD

• 背景：
• This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008],

• 功能：
• domain:The numerous interruptions in the triple helix may make this molecule either elastic or flexible.,function:May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Oligomer; disulfide-linked.,tissue specificity:Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.,

• 细胞定位：
• Secreted, extracellular space, extracellular matrix .

• 组织表达：
• Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.

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