• 靶点：
• CNOT2

• 简介：
• >>RNA degradation

• 基因名称：
• CNOT2

• 蛋白名称：
• CCR4-NOT transcription complex subunit 2

• Human Gene Id：
• 4848

• Human Swiss Prot No：
• Q9NZN8

• Mouse Gene Id：
• 72068

• Mouse Swiss Prot No：
• Q8C5L3

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CNOT2. AA range:67-116

• 特异性：
• CNOT2 Polyclonal Antibody detects endogenous levels of CNOT2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CNOT2;CDC36;NOT2;HSPC131;MSTP046;CCR4-NOT transcription complex subunit 2;CCR4-associated factor 2

• 实测条带：
• 46kD

• 背景：
• CCR4-NOT transcription complex subunit 2(CNOT2) Homo sapiens This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010],

• 功能：
• function:The CCR4-NOT complex functions as general transcription regulation complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CNOT2/3/5 family.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8.,tissue specificity:Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.,

• 细胞定位：
• Cytoplasm . Nucleus .

• 组织表达：
• Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.

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