CNG-1 Polyclonal Antibody
- 货号：YT0995
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Phototransduction
- 蛋白名称：
- cGMP-gated cation channel alpha-1
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human CNGA1. AA range:401-450
- 特异性：
- CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CNGA1;CNCG;CNCG1;cGMP-gated cation channel alpha-1;Cyclic nucleotide-gated cation channel 1;Cyclic nucleotide-gated channel alpha-1;CNG channel alpha-1;CNG-1;CNG1;Cyclic nucleotide-gated channel; photoreceptor;Rod photoreceptor cG
- 背景：
- The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
- 功能：
- caution:It is uncertain whether Met-1 or Met-5 is the initiator.,disease:Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subuni
- 细胞定位：
- Cell membrane ; Multi-pass membrane protein .
- 组织表达：
- Rod cells in the retina.
- Western Blot analysis of HepG2 cells using CNG-1 Polyclonal Antibody
- Western blot analysis of CNGA1 Antibody. The lane on the right is blocked with the CNGA1 peptide.
- Western blot analysis of the lysates from HepG2 cells using CNGA1 antibody.
