• 靶点：
• CLIP-170

• 简介：
• >>mTOR signaling pathway

• 基因名称：
• CLIP1

• 蛋白名称：
• CAP-Gly domain-containing linker protein 1

• Human Gene Id：
• 6249

• Human Swiss Prot No：
• P30622

• Mouse Gene Id：
• 56430

• Mouse Swiss Prot No：
• Q922J3

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CLIP1. AA range:1291-1340

• 特异性：
• CLIP-170 Polyclonal Antibody detects endogenous levels of CLIP-170 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CLIP1;CYLN1;RSN;CAP-Gly domain-containing linker protein 1;Cytoplasmic linker protein 1;Cytoplasmic linker protein 170 alpha-2;CLIP-170;Reed-Sternberg intermediate filament-associated protein;Restin

• 实测条带：
• 161kD

• 背景：
• The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

• 功能：
• function:Seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.,similarity:Contains 2 CAP-Gly domains.,subcellular location:Associated with the cytoskeleton.,tissue specificity:Highly expressed in the Reed-Sternberg cells of Hodgkin's disease.,

• 细胞定位：
• Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle . Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). .

• 组织表达：
• Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.

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