CLIC6 Polyclonal Antibody
- 货号：YT0966
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- Chloride intracellular channel protein 6
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human CLIC6. AA range:411-460
- 特异性：
- CLIC6 Polyclonal Antibody detects endogenous levels of CLIC6 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CLIC6;CLIC1L;Chloride intracellular channel protein 6;Parchorin
- 背景：
- chloride intracellular channel 6(CLIC6) Homo sapiens This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015],
- 功能：
- domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.,function:May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.,PTM:Phosphorylated.,similarity:Belongs to the chloride channel CLIC family.,similarity:Contains 1 GST C-terminal domain.,subcellular location:Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane.,subunit:Interacts with dopamine receptors DRD2, DRD3 and DRD4.,tissue specificity:Expressed in brain, placenta, pancreas and liver.,
- 细胞定位：
- Cytoplasm . Cell membrane ; Single-pass membrane protein . Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). .
- 组织表达：
- Expressed in brain, placenta, pancreas and liver.
- Western blot analysis of CLIC6 Antibody. The lane on the right is blocked with the CLIC6 peptide.
- Western blot analysis of the lysates from HepG2 cells using CLIC6 antibody.
