CLC-KA Polyclonal Antibody
- 货号：YT0963
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- Chloride channel protein ClC-Ka
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human CLCNKA. AA range:581-630
- 特异性：
- CLC-KA Polyclonal Antibody detects endogenous levels of CLC-KA protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CLCNKA;Chloride channel protein ClC-Ka;Chloride channel Ka;ClC-K1
- 背景：
- This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- 功能：
- function:Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.,similarity:Belongs to the chloride channel (TC 2.A.49) family.,similarity:Contains 2 CBS domains.,subunit:Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle.,tissue specificity:Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proreins.,
- 细胞定位：
- Membrane; Multi-pass membrane protein.
- 组织表达：
- Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
- Western Blot analysis of various cells using CLC-KA Polyclonal Antibody
- Western blot analysis of CLCNKA Antibody. The lane on the right is blocked with the CLCNKA peptide.
- Western blot analysis of the lysates from HepG2 cells using CLCNKA antibody.
