CKR-7 Polyclonal Antibody
- 货号:YT0938
- 应用:WB;IF;ELISA
- 种属:Human;Monkey
- 简介:
- >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway
- 蛋白名称:
- C-C chemokine receptor type 7
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human CCR7. AA range:170-219
- 特异性:
- CKR-7 Polyclonal Antibody detects endogenous levels of CKR-7 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- CCR7;CMKBR7;EBI1;EVI1;C-C chemokine receptor type 7;C-C CKR-7;CC-CKR-7;CCR-7;BLR2;CDw197;Epstein-Barr virus-induced G-protein coupled receptor 1;EBI1;EBV-induced G-protein coupled receptor 1;MIP-3 beta receptor;CD antigen CD19
- 背景:
- The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014],
- 功能:
- function:Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.,induction:By EBV.,online information:CC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.,
- 细胞定位:
- Cell membrane; Multi-pass membrane protein.
- 组织表达:
- Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
![](/uploadfiles/PIC/yt0938-wb.jpg)
- Western Blot analysis of COS-7 cells using CKR-7 Polyclonal Antibody
![](/uploadfiles/PIC/yt0938_pic821918522.jpg)
- Immunofluorescence analysis of A549 cells, using CCR7 Antibody. The picture on the right is blocked with the synthesized peptide.
![](/uploadfiles/PIC/yt0938_pic822018522.jpg)
- Western blot analysis of lysates from COS7 cells, using CCR7 Antibody. The lane on the right is blocked with the synthesized peptide.
![](/uploadfiles/PIC/yt0938_pic968918522.jpg)
- Western blot analysis of the lysates from HeLa cells using CCR7 antibody.