• 靶点：
• CEL

• 简介：
• >>Steroid biosynthesis;>>Glycerolipid metabolism;>>Metabolic pathways;>>Pancreatic secretion;>>Fat digestion and absorption

• 基因名称：
• CEL

• 蛋白名称：
• Bile salt-activated lipase

• Human Gene Id：
• 1056

• Human Swiss Prot No：
• P19835

• Mouse Swiss Prot No：
• Q64285

• 免疫原：
• Synthesized peptide derived from the Internal region of human CEL.

• 特异性：
• CEL Polyclonal Antibody detects endogenous levels of CEL protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CEL;BAL;Bile salt-activated lipase;BAL;Bile salt-stimulated lipase;BSSL;Bucelipase;Carboxyl ester lipase;Cholesterol esterase;Pancreatic lysophospholipase;Sterol esterase

• 分子量：
• 78kD

• 背景：
• The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:A steryl ester + H(2)O = a sterol + a fatty acid.,catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,disease:Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8) [MIM:609812]; also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY [MIM:606391] is an autosomal dominant form of diabetes mellitus. The pancreas serves both endocrine and exocrine functions. The endocrine cells are found in the islets of Langerhans. They synthesize insulin and other hormones, and are involved in the pathogenesis of diabetes mellitus. The exocrine cells produce bicarbonate and digestive enzymes and are involved in the pathogenesis of pancreatic malabsorption. The localization of the islets within exocrine pancreatic tissue is suggestive of an interdependency and cross-talk between these two cell

• 细胞定位：
• Secreted .

• 组织表达：
• Mammary gland and pancreas. Detected in pancreatic and duodenal juice (at protein level) (PubMed:21784842). Expressed by eosinophils.

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