CDHF10 Polyclonal Antibody
- 货号：YT0825
- 应用：IHC;IF;ELISA
- 种属：Human;Mouse;Rat
- 蛋白名称：
- Cadherin EGF LAG seven-pass G-type receptor 2
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human CELSR2. AA range:2781-2830
- 特异性：
- CDHF10 Polyclonal Antibody detects endogenous levels of CDHF10 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CELSR2;CDHF10;EGFL2;KIAA0279;MEGF3;Cadherin EGF LAG seven-pass G-type receptor 2;Cadherin family member 10;Epidermal growth factor-like protein 2;EGF-like protein 2;Flamingo homolog 3;Multiple epidermal growth factor-like domains
- 背景：
- The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008],
- 功能：
- function:Receptor that may have an important role in cell/cell signaling during nervous system formation.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 laminin EGF-like domain.,similarity:Contains 2 laminin G-like domains.,similarity:Contains 7 EGF-like domains.,similarity:Contains 9 cadherin domains.,tissue specificity:Highest expression in brain and testis.,
- 细胞定位：
- Cell membrane; Multi-pass membrane protein.
- 组织表达：
- Highest expression in brain and testis.
- Immunofluorescence analysis of COS7 cells, using CELSR2 Antibody. The picture on the right is blocked with the synthesized peptide.
- Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CELSR2 Antibody. The picture on the right is blocked with the synthesized peptide.
