• 靶点：
• CD164

• 简介：
• >>Lysosome

• 基因名称：
• CD164

• 蛋白名称：
• Sialomucin core protein 24

• Human Gene Id：
• 8763

• Human Swiss Prot No：
• Q04900

• Mouse Gene Id：
• 53599

• Mouse Swiss Prot No：
• Q9R0L9

• Rat Gene Id：
• 83689

• Rat Swiss Prot No：
• Q9QX82

• 免疫原：
• Synthesized peptide derived from CD164 . at AA range: 110-190

• 特异性：
• CD164 Polyclonal Antibody detects endogenous levels of CD164 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CD164;Sialomucin core protein 24;MUC-24;Endolyn;Multi-glycosylated core protein 24;MGC-24;MGC-24v;CD antigen CD164

• 分子量：
• 20kD

• 背景：
• Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 [PubMed 9680353]; Forde et al., 2007 [PubMed 17077324]).[supplied by OMIM, Aug 2008],

• 功能：
• function:This is a carcinoma-associated protein, probably a mucin.,PTM:Highly N- and O-glycosylated; contains sialic acid.,PTM:The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.,similarity:Belongs to the CD164 family.,tissue specificity:Small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma.,

• 细胞定位：
• Lysosome membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

• 组织表达：
• Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.

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