CD137L Polyclonal Antibody
- 货号：YT0723
- 应用：WB;IF;ELISA
- 种属：Human;Mouse
- 简介：
- >>Cytokine-cytokine receptor interaction
- 蛋白名称：
- Tumor necrosis factor ligand superfamily member 9
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human TNFSF9. AA range:31-80
- 特异性：
- CD137L Polyclonal Antibody detects endogenous levels of CD137L protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TNFSF9;Tumor necrosis factor ligand superfamily member 9;4-1BB ligand;4-1BBL
- 背景：
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided b
- 功能：
- function:Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer .,tissue specificity:Expressed in brain, placenta, lung, skeletal muscle and kidney.,
- 细胞定位：
- Membrane; Single-pass type II membrane protein.
- 组织表达：
- Expressed in brain, placenta, lung, skeletal muscle and kidney.
- Western Blot analysis of various cells using CD137L Polyclonal Antibody diluted at 1:1000
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- Western Blot analysis of HuvEc cells using CD137L Polyclonal Antibody diluted at 1:1000
- Immunofluorescence analysis of HeLa cells, using TNFSF9 Antibody. The picture on the right is blocked with the synthesized peptide.
- Western blot analysis of lysates from HUVEC cells, using TNFSF9 Antibody. The lane on the right is blocked with the synthesized peptide.
