• 靶点：
• Catenin-γ

• 简介：
• >>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Gastric cancer;>>Arrhythmogenic right ventricular cardiomyopathy

• 基因名称：
• JUP

• 蛋白名称：
• Junction plakoglobin

• Human Gene Id：
• 3728

• Human Swiss Prot No：
• P14923

• Mouse Gene Id：
• 16480

• Mouse Swiss Prot No：
• Q02257

• Rat Gene Id：
• 81679

• Rat Swiss Prot No：
• Q6P0K8

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Catenin-gamma. AA range:696-745

• 特异性：
• Catenin-γ Polyclonal Antibody detects endogenous levels of Catenin-γ protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• JUP;CTNNG;DP3;Junction plakoglobin;Catenin gamma;Desmoplakin III;Desmoplakin-3

• 实测条带：
• 82kD

• 背景：
• This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy type 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,disease:Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.,function:Common junctional plaque protein. The membrane-assoc

• 细胞定位：
• Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form.

• 组织表达：
• Cervix carcinoma,Epidermal carcinoma,Epithelium,Leukocyte,Lung,Lung carcinoma,Place

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