• 靶点：
• CaMKIIβ/γ

• 简介：
• >>ErbB signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>HIF-1 signaling pathway;>>Oocyte meiosis;>>Necroptosis;>>Adrenergic signaling in cardiomyocytes;>>Wnt signaling pathway;>>Axon guidance;>>Circadian entrainment;>>Long-term potentiation;>>Neurotrophin signaling pathway;>>Cholinergic synapse;>>Dopaminergic synapse;>>Olfactory transduction;>>Inflammatory mediator regulation of TRP channels;>>Insulin secretion;>>GnRH signaling pathway;>>Melanogenesis;>>Oxytocin signaling pathway;>>Glucagon signaling pathway;>>Aldosterone synthesis and secretion;>>Cushing syndrome;>>Gastric acid secretion;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases;>>Amphetamine addiction;>>Tuberculosis;>>Pathways in cancer;>>Proteoglycans in cancer;>>Glioma;>>Diabetic cardiomyopathy;>>Lipid and atherosclerosis

• 基因名称：
• CAMK2B/CAMK2G

• 蛋白名称：
• Calcium/calmodulin-dependent protein kinase type II subunit beta/gamma

• Human Gene Id：
• 818/816

• Human Swiss Prot No：
• Q13555/Q13554

• Mouse Gene Id：
• 12325/12323

• Rat Gene Id：
• 171140/24245

• Rat Swiss Prot No：
• P11730/P08413

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CaMK2 beta/gamma. AA range:509-558

• 特异性：
• CaMKIIβ/γ Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CAMK2G;CAMK;CAMK-II;CAMKG;Calcium/calmodulin-dependent protein kinase type II subunit gamma;CaM kinase II subunit gamma;CaMK-II subunit gamma;CAMK2B;CAM2;CAMK2;CAMKB;Calcium/calmodulin-dependent protein kinase type II subunit bet

• 实测条带：
• 62kD

• 背景：
• The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011],

• 功能：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,

• 细胞定位：
• Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .

• 组织表达：
• Expressed in skeletal muscle.

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