• 靶点：
• CA XIV

• 简介：
• >>Nitrogen metabolism;>>Metabolic pathways

• 基因名称：
• CA14

• 蛋白名称：
• Carbonic anhydrase 14

• Human Gene Id：
• 23632

• Human Swiss Prot No：
• Q9ULX7

• Mouse Gene Id：
• 23831

• Mouse Swiss Prot No：
• Q9WVT6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CA14. AA range:161-210

• 特异性：
• CA XIV Polyclonal Antibody detects endogenous levels of CA XIV protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CA14;Carbonic anhydrase 14;Carbonate dehydratase XIV;Carbonic anhydrase XIV;CA-XIV

• 实测条带：
• 34kD

• 背景：
• Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.,

• 细胞定位：
• Membrane ; Single-pass type I membrane protein .

• 组织表达：
• High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.

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