• 靶点：
• CA VB

• 简介：
• >>Nitrogen metabolism;>>Metabolic pathways

• 基因名称：
• CA5B

• 蛋白名称：
• Carbonic anhydrase 5B mitochondrial

• Human Gene Id：
• 11238

• Human Swiss Prot No：
• Q9Y2D0

• Mouse Gene Id：
• 56078

• Mouse Swiss Prot No：
• Q9QZA0

• Rat Gene Id：
• 302669

• Rat Swiss Prot No：
• Q66HG6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CA5B. AA range:241-290

• 特异性：
• CA VB Polyclonal Antibody detects endogenous levels of CA VB protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CA5B;Carbonic anhydrase 5B; mitochondrial;Carbonate dehydratase VB;Carbonic anhydrase VB;CA-VB

• 实测条带：
• 38kD

• 背景：
• Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.,

• 细胞定位：
• Mitochondrion.

• 组织表达：
• Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.

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