• 靶点：
• CA III

• 简介：
• >>Nitrogen metabolism;>>Metabolic pathways

• 基因名称：
• CA3

• 蛋白名称：
• Carbonic anhydrase 3

• Human Gene Id：
• 761

• Human Swiss Prot No：
• P07451

• Mouse Gene Id：
• 12350

• Mouse Swiss Prot No：
• P16015

• Rat Gene Id：
• 54232

• Rat Swiss Prot No：
• P14141

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CA3. AA range:141-190

• 特异性：
• CA III Polyclonal Antibody detects endogenous levels of CA III protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CA3;Carbonic anhydrase 3;Carbonate dehydratase III;Carbonic anhydrase III;CA-III

• 实测条带：
• 38kD

• 背景：
• Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008],

• 功能：
• catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,developmental stage:At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.,function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:Muscle specific.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Muscle specific.

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