• 靶点：
• BMP-2

• 简介：
• >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Pathways in cancer;>>Basal cell carcinoma

• 基因名称：
• BMP2

• 蛋白名称：
• Bone morphogenetic protein 2

• Human Gene Id：
• 650

• Human Swiss Prot No：
• P12643

• Mouse Gene Id：
• 12156

• Mouse Swiss Prot No：
• P21274

• Rat Gene Id：
• 29373

• Rat Swiss Prot No：
• P49001

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human BMP-2. AA range:226-275

• 特异性：
• BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IF 1:50-200 WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• BMP2;BMP2A;Bone morphogenetic protein 2;BMP-2;Bone morphogenetic protein 2A;BMP-2A

• 实测条带：
• 60kD

• 背景：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016],

• 功能：
• function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.,

• 细胞定位：
• Secreted.

• 组织表达：
• Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

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Functionalized Polycaprolactone/Hydroxyapatite Composite Microspheres for Promoting Bone Consolidation in a Rat Distraction Osteogenesis Model. JOURNAL OF ORTHOPAEDIC RESEARCH 2019 Dec 05 IHC Rat 1:100 tibiae
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Enhancing cranial defect repair in rats: investigating the effect of combining Total Flavonoids from Rhizoma Drynariae with calcium phosphate/collagen scaffolds Journal of Orthopaedic Surgery and Research Yu Lan IHC Rat 1:1200 bone tissue
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Longitudinal skeletal growth and growth plate morphological characteristics of chondro-tissue specific CUL7 knockout mice ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER Yanan Zhang IHC,WB Mouse 1:1000,1:500 bone tissue
货号：YT0498

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