• 靶点：
• ATG4A

• 简介：
• >>Autophagy - other;>>Autophagy - animal

• 基因名称：
• ATG4A

• 蛋白名称：
• Cysteine protease ATG4A

• Human Gene Id：
• 115201

• Human Swiss Prot No：
• Q8WYN0

• Mouse Gene Id：
• 666468

• Mouse Swiss Prot No：
• Q8C9S8

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ATG4A. AA range:81-130

• 特异性：
• Atg4A Polyclonal Antibody detects endogenous levels of Atg4A protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ATG4A;APG4A;AUTL2;Cysteine protease ATG4A;AUT-like 2 cysteine endopeptidase;Autophagin-2;Autophagy-related cysteine endopeptidase 2;Autophagy-related protein 4 homolog A;hAPG4A

• 分子量：
• 45kD

• 背景：
• Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016],

• 功能：
• enzyme regulation:Inhibited by N-ethylmaleimide.,function:Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.,similarity:Belongs to the peptidase C54 family.,tissue specificity:Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Epithelium,Kidney,Ovary,Prostate,Testis,

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