• 靶点：
• Arp3

• 简介：
• >>Endocytosis;>>Tight junction;>>Fc gamma R-mediated phagocytosis;>>Regulation of actin cytoskeleton;>>Bacterial invasion of epithelial cells;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Yersinia infection

• 基因名称：
• ACTR3

• 蛋白名称：
• Actin-related protein 3

• Human Gene Id：
• 10096

• Human Swiss Prot No：
• P61158

• Mouse Gene Id：
• 74117

• Mouse Swiss Prot No：
• Q99JY9

• Rat Gene Id：
• 81732

• Rat Swiss Prot No：
• Q4V7C7

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ACTR3. AA range:369-418

• 特异性：
• Arp3 Polyclonal Antibody detects endogenous levels of Arp3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ACTR3;ARP3;Actin-related protein 3;Actin-like protein 3

• 实测条带：
• 47kD

• 背景：
• The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013],

• 功能：
• function:Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.,similarity:Belongs to the actin family.,similarity:Belongs to the actin family. ARP3 subfamily.,subunit:Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1.,

• 细胞定位：
• Cytoplasm, cytoskeleton . Cell projection . Nucleus . In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).

• 组织表达：
• Brain,Cajal-Retzius cell,T-cell,

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