ARHGEF10 Polyclonal Antibody
- 货号:YT0321
- 应用:WB;IHC;IF;ELISA
- 种属:Human;Monkey
- 蛋白名称:
- Rho guanine nucleotide exchange factor 10
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human ARHGEF10. AA range:339-388
- 特异性:
- ARHGEF10 Polyclonal Antibody detects endogenous levels of ARHGEF10 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- ARHGEF10;KIAA0294;Rho guanine nucleotide exchange factor 10
- 背景:
- This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
- 功能:
- disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.,function:May play a role in developmental myelination of peripheral nerves.,sequence caution:Cloning artifact.,sequence caution:Translated as Lys.,similarity:Contains 1 DH (DBL-homology) domain.,
- 细胞定位:
- centrosome,cytosol,
- 组织表达:
- Amygdala,Brain,Duodenum,Prostate,Testis,Uterus,
![](/uploadfiles/PIC/yt0321-wb.jpg)
- Western Blot analysis of various cells using ARHGEF10 Polyclonal Antibody
![](/uploadfiles/PIC/yt0321_pic747618522.jpg)
- Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using ARHGEF10 Antibody. The picture on the right is blocked with the synthesized peptide.
![](/uploadfiles/PIC/yt0321_pic747718522.jpg)
- Western blot analysis of lysates from COS7 cells, using ARHGEF10 Antibody. The lane on the right is blocked with the synthesized peptide.