ARALAR Polyclonal Antibody
- 货号：YT0305
- 应用：WB;IHC;IF;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- Calcium-binding mitochondrial carrier protein Aralar1
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human CMC1. AA range:391-440
- 特异性：
- ARALAR Polyclonal Antibody detects endogenous levels of ARALAR protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- SLC25A12;ARALAR1;Calcium-binding mitochondrial carrier protein Aralar1;Mitochondrial aspartate glutamate carrier 1;Solute carrier family 25 member 12
- 背景：
- This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012],
- 功能：
- function:Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle.,miscellaneous:Binds calcium.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,similarity:Contains 4 EF-hand domains.,tissue specificity:High levels in heart and skeletal muscle, low in brain and very low in kidney.,
- 细胞定位：
- Mitochondrion inner membrane ; Multi-pass membrane protein .
- 组织表达：
- Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney.
- Western Blot analysis of various cells using ARALAR Polyclonal Antibody diluted at 1:1000
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- Western Blot analysis of HEPG2 cells using ARALAR Polyclonal Antibody diluted at 1:1000
- Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using CMC1 Antibody. The picture on the right is blocked with the synthesized peptide.
