AR α2B Polyclonal Antibody
- 货号：YT0299
- 应用：IF;ELISA
- 种属：Human;Rat;Mouse;
- 简介：
- >>cGMP-PKG signaling pathway;>>Neuroactive ligand-receptor interaction
- 蛋白名称：
- Alpha-2B adrenergic receptor
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2B. AA range:161-210
- 特异性：
- AR α2B Polyclonal Antibody detects endogenous levels of AR α2B protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ADRA2B;ADRA2L1;ADRA2RL1;Alpha-2B adrenergic receptor;Alpha-2 adrenergic receptor subtype C2;Alpha-2B adrenoreceptor;Alpha-2B adrenoceptor;Alpha-2BAR
- 背景：
- This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014],
- 功能：
- function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.,polymorphism:A rare polymorphic framshift in position 451 produces a protein of 542 residues.,similarity:Belongs to the G-protein coupled receptor 1 family.,
- 细胞定位：
- Cell membrane ; Multi-pass membrane protein . Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. .
- Immunofluorescence analysis of HepG2 cells, using Adrenergic Receptor alpha-2B Antibody. The picture on the right is blocked with the synthesized peptide.
