• 靶点：
• Amylin

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Maturity onset diabetes of the young

• 基因名称：
• IAPP

• 蛋白名称：
• Islet amyloid polypeptide

• Human Gene Id：
• 3375

• Human Swiss Prot No：
• P10997

• Mouse Swiss Prot No：
• P12968

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Amylin. AA range:1-50

• 特异性：
• Amylin Polyclonal Antibody detects endogenous levels of Amylin protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IAPP;Islet amyloid polypeptide;Amylin;Diabetes-associated peptide;DAP;Insulinoma amyloid peptide

• 实测条带：
• 25kD

• 背景：
• islet amyloid polypeptide(IAPP) Homo sapiens This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016],

• 功能：
• disease:IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.,function:Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.,online information:Amylin entry,similarity:Belongs to the calcitonin family.,

• 细胞定位：
• Secreted .

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