• 靶点：
• Amphiphysin I

• 简介：
• >>Endocytosis;>>Fc gamma R-mediated phagocytosis

• 基因名称：
• AMPH

• 蛋白名称：
• Amphiphysin

• Human Gene Id：
• 273

• Human Swiss Prot No：
• P49418

• Mouse Gene Id：
• 218038

• Mouse Swiss Prot No：
• Q7TQF7

• Rat Gene Id：
• 60668

• Rat Swiss Prot No：
• O08838

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human AMPH. AA range:131-180

• 特异性：
• Amphiphysin I Polyclonal Antibody detects endogenous levels of Amphiphysin I protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• AMPH;AMPH1;Amphiphysin

• 实测条带：
• 76kD

• 背景：
• This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010],

• 功能：
• disease:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms.,function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.,similarity:Contains 1 BAR domain.,similarity:Contains 1 SH3 domain.,subunit:Heterodimer with BIN1. Binds SH3GLB1 and AP2A2.,tissue specificity:Neurons, certain endocrine cell types and spermatocytes.,

• 细胞定位：
• Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

• 组织表达：
• Neurons, certain endocrine cell types and spermatocytes.

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