• 靶点：
• AMPD1

• 简介：
• >>Purine metabolism;>>Metabolic pathways;>>Nucleotide metabolism

• 基因名称：
• AMPD1

• 蛋白名称：
• AMP deaminase 1

• Human Gene Id：
• 270

• Human Swiss Prot No：
• P23109

• Mouse Swiss Prot No：
• Q3V1D3

• Rat Gene Id：
• 25028

• Rat Swiss Prot No：
• P10759

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human AMPD1. AA range:261-310

• 特异性：
• AMPD1 Polyclonal Antibody detects endogenous levels of AMPD1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• AMPD1;AMP deaminase 1;AMP deaminase isoform M;Myoadenylate deaminase

• 分子量：
• 86kD

• 背景：
• Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010],

• 功能：
• catalytic activity:AMP + H(2)O = IMP + NH(3).,disease:Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type (AMPDDM) [MIM:102770]. AMPDDM is a metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue.,function:AMP deaminase plays a critical role in energy metabolism.,pathway:Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.,similarity:Belongs to the adenosine and AMP deaminases family.,subunit:Homotetramer.,tissue specificity:Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.,

• 细胞定位：
• cytosol,

• 组织表达：
• Skeletal muscle,

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