• 靶点：
• AMID

• 简介：
• >>p53 signaling pathway

• 基因名称：
• AIFM2

• 蛋白名称：
• Apoptosis-inducing factor 2

• Human Gene Id：
• 84883

• Human Swiss Prot No：
• Q9BRQ8

• Mouse Gene Id：
• 71361

• Mouse Swiss Prot No：
• Q8BUE4

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human AIFM2. AA range:141-190

• 特异性：
• AMID Polyclonal Antibody detects endogenous levels of AMID protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• AIFM2;AMID;PRG3;Apoptosis-inducing factor 2;Apoptosis-inducing factor homologous mitochondrion-associated inducer of death;Apoptosis-inducing factor-like mitochondrion-associated inducer of death;p53-responsive gene 3 protein

• 实测条带：
• 41kD

• 背景：
• This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010],

• 功能：
• cofactor:FAD. Binds 6-hydroxy-FAD non-covalently.,function:Oxidoreductase, which may play a role in mediating a TP53/p53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.,induction:Expression detected at 4 hours after induction by TP53/p53. Down-regulated in a wide range of human tumors.,similarity:Belongs to the FAD-dependent oxidoreductase family.,tissue specificity:Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following TP53/p53 induction. The shorter 1.8 kb transcript seems to be the major tra

• 细胞定位：
• Lipid droplet . Cell membrane ; Lipid-anchor . Cytoplasm . Mitochondrion membrane . Nucleus .

• 组织表达：
• Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.

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