• 靶点：
• ALS

• 简介：
• >>Growth hormone synthesis, secretion and action

• 基因名称：
• IGFALS

• 蛋白名称：
• Insulin-like growth factor-binding protein complex acid labile subunit

• Human Gene Id：
• 3483

• Human Swiss Prot No：
• P35858

• Mouse Swiss Prot No：
• P70389

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human IGFALS. AA range:303-352

• 特异性：
• ALS Polyclonal Antibody detects endogenous levels of ALS protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IGFALS;ALS;Insulin-like growth factor-binding protein complex acid labile subunit;ALS

• 实测条带：
• 66kD

• 背景：
• The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],

• 功能：
• function:Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.,similarity:Contains 20 LRR (leucine-rich) repeats.,subunit:Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.,tissue specificity:Plasma.,

• 细胞定位：
• Secreted, extracellular space.

• 组织表达：
• Plasma.

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